하수오 지상부의 활성 성분

• 영문명: Active Compounds from The Aerial Parts of Polygonum multiflorum Thunberg
• 발행기관: 대한약학회
• 저자명: 김진표(Jin Pyo Kim) 김도훈(Do Hoon Kim) 김기은(Gi Eun Kim) 김진효(Jin-Hyo Kim)정성희(Sung Hee Chung) 김성건(Sung Gun Kim) 황완균(Wan Kyunn Whang)
• 간행물 정보: 『약학회지』제50권 제6호 (2006년), 351~357쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.12.31

영문 초록

Polygoni Radix (Polygonaceae) has been used as renal disorder, hematopoietic, menstrual irregularity and anti-aging in Korean folk medicine. Specially aerial parts has been used for insomnia and sedative agent. In order to investigate the efficacy of antioxidant activity on these aerial parts, the bio-activity guided fraction and isolation of physiologically active substance were performed. H2O, 30%, 60%, 100% MeOH were examined antioxidant activity by DPPH method. It was revealed that 30%, 60% MeOH fractions have significantly antioxidant activity. From 60% MeOH fraction, six known flavonoid glycosides (quercetin, quercetin 3-O-β-D-galactopyranosyl-4'-O-glucopyranoside-3'-methylether, quercetin 3-O-α-L-rhamnopyranoside, quercetin 3-O-α-L-rhamnophyrano side-4'-methylether, quercetin 3-O-β-D-galactopyranoside, quercetin 3-O-β-D-glucopyranoside) and 3,4-dihydrocinnamic acid were isolated. To investigated the antioxidant activities of each compounds, we measured radical scavening activity with DPPH method and anti-lipid peroxidative efficacy on low density lipo-protein(LDL) with TBARS assay and anti-acetylcholinestrase activity with Ellman's Test. Four compounds (Ⅱ,Ⅳ,Ⅵ,Ⅷ) of quercetin glycosides showed significant activity.

키워드

Polygonum multiflorum DPPH method TBARS assay Ellman's Test quercetin glycosides