세포탁심나트륨과 세프트리악손나트륨의 전기화학 거동 및 네모파 전압전류법 정량

• 영문명: Electrochemical Behaviors and Square Wave Voltammetric Determinations of Cefotaxime Sodium and Ceftriaxone Sodium
• 발행기관: 대한약학회
• 저자명: 김민경(Min Kyung Kim) 한영희(Young Hee Hahn)
• 간행물 정보: 『약학회지』제50권 제1호 (2006년), 40~46쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.02.28

영문 초록

Square wave voltammetric (SWV) and cyclic vlotammetric (CV) behaviors of cefotaxime sodium and ceftriaxone sodium have been investigated in the potential range between -0.10V and -1.30V using the phosphate buffers of various pH values (2.00~9.10). Two main peaks observed were irreversible and protons were involved in their electrochemical reductions. The first peaks of these cephalosporin antibiotics are due to the reduction of the azomethine double bond in the methoxyimino group of the side chain at position 7. The second peaks of cefotaxime sodium and ceftriaxone sodium are related to the reductions of the △3 double bond and the dioxo moiety of the side chain at position 3, respectively. The calibration curve of cefotaxime sodium in the concentration range between 1.0×10-7M and 1.0×10-5M yielded the linearity with the correlation coefficient of 0.9998 when the first peak of the antibiotic in a phosphate buffer of pH 3.02 was measured at the conditions of frequency of 120 Hz and pulse height of 50 mV by SWV. The present fast, simple and accurate SWV assay method was applied to determine cefotaxime sodium in the commercial antibiotic powder of injection.

키워드

cefotaxime sodium ceftriaxone sodium square wave voltammetry