Isoflavonoid의 피부염증균에 대한 항균 및 항산화효과

• 영문명: Antimicrobial and Antioxidative Effects of Isoflavonoids on Skin Microbial Inflammation Pathogens
• 발행기관: 대한약학회
• 저자명: 신정미(Jung Mi Shin) 유형원(Hung Won Yu) 이현옥(Hyun Ok Lee) 이미희(Mi Hee Lee) 백승화(Seung Hwa Baek)
• 간행물 정보: 『약학회지』제50권 제1호 (2006년), 15~20쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.02.28

영문 초록

Puerarin and daidzin have been isolated from Puerariae thunbergiana Benth. Structures were determined by spectroscopic methods. Compounds showed weak antimicrobial activity against S. mutans, S. epidermidis, S. aureus, and C. albicans (MIC, 800㎍/㎖). However, these compounds were not antioxidative. Puerariae thunbergiana Benth. extracts against microorgani는 were evaluated in terms of the minimum inhibitory concentrations (MIC). In general, C. albicans was stronger antimicrobial activity than the other microorgani는. The antioxidative activity of was observed in the etyl acetate extract (IC50, 119.87±0.16㎍/㎖). The DPPH radical scavenging effect (IC50, 1,673.3±0.54μM) of the puerarin was comparable with that of synthetic antioxidant, BHA(IC50, 88.39±1.1)×10-3 μM. These results suggest that puerarin and daidzin have a potential antimicrobial activity.

키워드

Puerariae thunbergiana Benth antimicrobial effects minimum inhibitory concentration(MIC)