모세관 전기영동법을 이용한 베타차단제 -시클로덱스트린 포접화합물의 안정도상수 결정

• 영문명: Determination of Stability Constants for β-Blocker and Carboxymethyl-β-cyclodextrin Complexes by Capillary Electrophoresis
• 발행기관: 대한약학회
• 저자명: 박경래(Kyung Rae Park) 임환미(Hwan Mi Lim) 뉴엔티퐁(Nguyen Thi Phuong) 김경호(Kyeong Ho Kim) 강종성(Jong Seong Kang)
• 간행물 정보: 『약학회지』제47권 제4호 (2003년), 200~205쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.08.30

영문 초록

The stability constants for the inclusion complexes between carboxymethyl-β- cyclodextrin (CM-β-CD) and five β-blockers, such as atenolol (ATE), bisoprolol (BIS), metoprolol (MET), pindolol (PIN) and propranolol (PRO) were determined by capillary electrophoresis. The magnitude of stability was decreased as following order; PRO>MET>BIS> ATE>PIN. Among them PRO showed the highest affinity towards CM-β- CD with stability constants of 383 and 371 M-1 for (R)- and (S)-enantiomer respectively: PIN enantiomers showed the lowest stability towards CM-β-CD, while the selectivity between (R)- and (S)-enantiomer was higher than any other tested β- blocker.

키워드

β-blocker cyclodextrin stability constant capillary electrophoresis.