GC/MS를 이용한 모발 중 MDMA(Methylendedioxymethamphetamine)의 분석

• 영문명: Analysis of 3,4-Methylenedioxymethamphetamine (MDMA) in Human Hair by Gas Chromatography/Mass Specirometry
• 발행기관: 대한약학회
• 저자명: 박미정(Meejung Park) 김은미(Eunmi Kim) 임미애(Miae Lim) 정희선(Heesun Chung)
• 간행물 정보: 『약학회지』제47권 제4호 (2003년), 195~199쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.08.30

영문 초록

An analysis method for the determination of methylenedioxymethamphetamine (MDMA) and its metabolite methylenedioxymethamphetamine (MDMA) in hair by gas chromatography/mass spectrometry was proposed. For MDMA and MDA analysis, hair samples were incubated in MeOH (1% HCl), derivatized with trifluoroacetic anhydride and assayed by GC/MS. Hair of 18 subjects for drug abuse was analysed for MDMA and MDA. Calibration curves for the determination of MDMA and MDA in hair showed a good linearity at a concentration range from 0.5 ng to 250 ng (r2=0.999) The extraction recovery was determined from hair blanks at 50, 100 ng. The percentage of recovery were found to be 96.08~103.48 with CV value of 1.62~3.89. The concentrations of MDMA and MDA ranged 1.14~38.06 ng/mg and 0.07~3.91 ng/mg, respectively in 18 hair samples from MDMA abusers. The ratio of MDMA to MDA ranged from 9.65~28.46 in all specimen. Hair analysis for MDMA is a useful method for identification of long-term drug abuser.

키워드

methylenedioxymethamphetamine(MDMA) methylenedioxyamphetamine(MDA) hair analysis GC/MS.