Streptozotocin 유발 당뇨 횐쥐에서 백삼 에탄올엑스와 IH-901의 항당뇨 작용 비교

• 영문명: Comparisons of Antidiabetic Actlvities between White Ginseng Ethanol and IH-901 in Streptozotocin-Induced Diabetic Rats
• 발행기관: 대한약학회
• 저자명: 고성권(Sung Kwon Ko) 성종환(Jong Hwan Sung) 최용의(Yong Eui Choi) 이충렬(Chung Ryul Lee) 박경수(Kyeong Soo Park) 정성현(Sung Hyun Chung)
• 간행물 정보: 『약학회지』제47권 제1호 (2003년), 52~55쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.02.28

영문 초록

Antidiabetic activities of white ginseng 50% ethanol extract (WGE) and IH901, an intestinal metabolite of ginsenoside Rbl, were compared in multiple low dose streptozotocin (STZ)-induced diabetic rats. WGE or IH901 were coad-ministered with STZ on Day 1 at dose of 100 and 300 mg or 10 and 30 mg, respectively; and continually administered for 16 days. STZ dissolved in citrate buffer was injected intraperitoneally at dose of 20 mg/kg for 5 consecutive days. During the experiment, plasma glucose level and body weight were measured every 4th day. Amount of food and water intake were evaluated once a week and compared between groups. WGE and IH901 both significantly reduced the plasma glucose levels on Day 16 as compared with those of the diabetic control group. In the meantime, amount of food and water intake in WGE- and IH901-treated groups were significantly improved in a dose dependent fashion as compared with those of the diabetic control group. Taken together, WGE and IH901 showed the comparable antidiabetic activities at the corresponding doses used in this experiment.

키워드

IH-901 metabolite of ginsenoside Rb1 multiple low dose streptozotocin antidiabetic activity.