Monoterpenes의 항암작용과 활성산소 전환 효소의 활성 변화

• 영문명: Anticancer Activity of Monoterpenes and the Changes of Enzymes Activities Responsible for the Conversion of Reactive Oxygen Species
• 발행기관: 대한약학회
• 저자명: 조용선(Young Sun Cho) 김수진(Soo Jin Kim) 박시원(Sie Won Park)
• 간행물 정보: 『약학회지』제47권 제1호 (2003년), 37~45쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2003.02.28

영문 초록

The present study was undertaken to investigate the anticancer activity of monoterepenes in the animal and the cancer cell line tests. Both of the noncyclic and cyclic monoterpenes showed significant life prolonging effects on ICR mouse with abdominal cancer induced by Sarcoma 180 cells up to 67.4% and 63.5% in case of linalool and geraniol, respectively: Linalool and geraniol also exhibited very excellent cytotoxicity against L1210 leukemic cells with IC50 value of 0.32 μg/ml in 5 days culture condition. In the presence of linalool and geraniol, the generation of 02- ion were found to be increased proportionally to the cytotoxicity arisen from these monoterpenes. Furthermore, the antioxidant enzymes activities such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) responsible for the conversion of 02- ion to H2O2 and then to H2O augmented remarkably by linalool and geraniol. All data put together it can be postulated that monoterpenes may kill abdominal cancer cells of ICR mouse probably by activating anticancer system of the bodyl whereas the death of L1210 cells may be due to the detrimental attacks of reactive oxygen species (ROS) including O2- in spite of antioxidant enzymes activities to overcome the ROS attacks.

키워드

Monoterpenes anticancer activity L1210 cells reactive oxygen species antioxidant enzymes.