Stop-flow 방법으로 분석한 Guanethidine의 이뇨작용

• 영문명: Stop-flow Analysis of the Diuretic Action of Guanethidine in the Dog
• 발행기관: 대한약학회
• 저자명: 고석태(Suk Tai Ko) 김성원(Sung Wun Kim) 김성오(Sung Oh Kim)
• 간행물 정보: 『약학회지』제19권 제4호 (1975년), 227~233쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1975.12.31

영문 초록

The diuretic action of guanethidine was investigated in the dogs by means of the stop-flow technique. Guanethidine increased the rejection of sodium in the ascending limb of Henle''s loop, as wellas in the proximal and distal tubules, resulting in the decrease of the concentrating ability of the kidney, in marked natriuresis and diuresis. It was also effective during an osmotic diuresis, which was induced by in fusing 10% mannitol solution intravenously with a speed of 10ml/min. The drug can exhibit its effect even under the diuretic action of mercurophylline, suggesting a different mechanism from that of mercuric diuretics.