증식성 염증의 재증식과정에 따른 Protocollagen Proline Hydroxylase의 활성

• 영문명: Protocollagen Proline Hydroxylase Activity in the Course of Rebound of Proliferative Inflammation
• 발행기관: 대한약학회
• 저자명: 신국현(Kuk Hyun Shin)
• 간행물 정보: 『약학회지』제19권 제4호 (1975년), 234~239쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1975.12.31

영문 초록

Protocollagen proline hydroxylase (PPH) activity in the course of rebound of rat carrageenin granuloma was assayed to investigate its relationship with collagen biosynthesis. The specific activity of PPH which was inhibited significantly by treatments with hydrocortisone acetate (3mg/kg/day, 3days) was recovered near to the normal level by 48 hr after the cessation of the corticoid treatments. The total enzyme activity of the granuloma of treated group was not yet recovered even on the 3rd day, still showing a significant difference from control. PPH activity expressed in terms of granuloma cells between control and the drug treated group, however, was changed showing no apparent difference throughout the experimental period. These results suggested that the synthesis of protocollagen (collagen precursor) rather than PPH activity was directly affected by administration and withdrawal of corticoid.