4-(2''-(N-(1-메틸-3-(3''-카바밀페닐)-n-프로필))아미노에틸)-1-히드록시-2-피리돈의 합성

• 영문명: Synthesis of 4-(2''-(N-(l-methyl-3''-carbamylphenyl)-n-propyl))-aminoethyl)-l-hydroxy-2-pyridone
• 발행기관: 대한약학회
• 저자명: 윤성화(Sung Hwa Yoon)
• 간행물 정보: 『약학회지』제37권 제1호 (1993년), 36~40쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.02.28

영문 초록

The 4-(2''-(N-(l-methyl-3''-carbamylphenyl)-n-propyl))aminoethyl)-l-hydroxy-2-pyridone which has isoelectronic and isosteric structural similarity with dobutamine without having the Catechol-O-Methyltransferase(COMT) vulnerable m-hydroxy group was synthesized via 12 synthetic steps.

키워드

Dobutamine cardiotonics l-hydroxy-2-pyridone reductive amination isostere.