Lewis Lung Carcinoma(LLC) 이식 생쥐에 있어서 천연운지 단백다당체(Copolang)의 면역조절활성

• 영문명: Immunomodulating Activities of Copolang, a Proteopolysaccharide from Coriolus versicolor in Lewis Lung Carcinoma (LLC) Bearing mice
• 발행기관: 대한약학회
• 저자명: 문창규(Chang Kiu Moon) 임철홍(Cheol Hong Lim) 목명수(Myung Soo Mock) 양경미(Kyung Mee Yang) 한혜승(Hye Seung Han) 최재영(Jae Young Choi)
• 간행물 정보: 『약학회지』제37권 제1호 (1993년), 9~17쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.02.28

영문 초록

Immune functions of mice bearing Lewis Lung Carcinoma (LLC) were significantly suppressed when evaluated with mitogen responsiveness, IL-2 production and non-specific suppressor activity. Based on these immunosuppressive characteristics of LLC bearing mice, immunomodulating activates of Copolang were investigated in this model. After 15 days of LLC inoculation, Copolang was intraperitoneally administered for 7 consecutive days with doses of 20 or 200 mg/kg. Immune functions were evaluated 3 days after the final administration of Copolang. The results showed that the growth of LLC solid tumor was not inhibited by Copolang. But, mitogens-induced proliferation, IL-2 production and responsiveness to recombinant IL-2 of splenocytes were significantly augmented by the treatment of Copolang. However suppressor cell activity was not affected by Copolang. These results indicate that Copolang expresses potent immunomodulating activates through the augmentations of IL-2 production and responsiveness to recombinant IL-2, which have been generally known to be suppressed in tumor bearing mice, without affecting the growth of tumor.

키워드

Copolang Coriolus versicolor immunomodulator Lewis Lung Carcinoma (LLC) mitogen induced splenocyte proliferation IL-2 release responsiveness to recombinant IL-2 nonspecific suppressor activity.