HPLC를 이용한 뇨 및 혈액중의 Pancuronium Bromide의 미량분석

• 영문명: Microanalysis of Pancuronium Bromide in Urine and Blood by HPLC
• 발행기관: 대한약학회
• 저자명: 김박광(Bak Kwang Kim) 김양숙(Tang Sook Kim) 박성배(Sung Bae Park) 이종숙(Jong Sook Rhee) 정규혁(Kyu Hyuck Jung), 김경님(Kyung Nim Kim)
• 간행물 정보: 『약학회지』제37권 제1호 (1993년), 30~35쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.02.28

영문 초록

HPLC/fluorescence detection method for the analysis of pancuronium bromide in biological fluids was developed. The method depends on the formation of insoluble red complex between pancuronium bromide and rose bengal in aqueous layer. This complex is quantitatively extracted from aqueous layer into chloroform layer. The complex is stable for 1 day in chloroform layer at room temperature. It was possible to analyze pancuronium bromide in the range of 0.05-0.5 mcg/ml without the effect of co-prescribed drugs.

키워드

Pancuronium bromide rose bengal ion pair extraction HPLC analysis