안지오테신 변환효소 억제 작용 물질의 합성

• 영문명: Synthesis of Angiotensin Converting Enzyme Inhibitors
• 발행기관: 대한약학회
• 저자명: 이희주(Hee Joo Lee) 김영숙(Young Sook Kim) 장영(Young Chang) 이종란(Jong Ran Lee) 윤혜숙(Hye Sook Yun-Choi)
• 간행물 정보: 『약학회지』제28권 제6호 (1984년), 313~319쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1984.12.30

영문 초록

Phenylurea, phenylthiourea, benzylcarbamate and toluenesulfonate of L-alanyl-L-proline(comp. 3~6) were synthesized and their effects against angiotensin-converting enzyme (ACE) were tested. Comp. 3 showed only mild inhibitory activities against ACE while comp. 4~6 were inert indicating that those functional groups were not suitable for interactions with ACE. Ortho-hydroxy- or ortho-carboxy-benzamide of proline (comp. 7) and phenylalanine (comp. 8 and 9) were also tested. Of the benzamides, ortho-hydroxy function was unsuitable to exert inhibitory activities against ACE. Ortho-carboxy group of 9 seemed to have mild interactions with active site of ACE possibly because of the shorter distance between the amide and ortho-carboxyl group of the compound than the corresponding two active sites of the enzyme.