흰쥐 뇌에서의 Presynaptic alpha-Receptor와 MAO 활성의 상관 관계

• 영문명: The Relationship between Presynaptic alpha-Receptor and Monoamine Oxidase Activity in the Rat Brain
• 발행기관: 대한약학회
• 저자명: 이경주(Kyoung Joo Lee) 김낙두(Nak Doo Kim) 고광호(Kwang Ho Ko)
• 간행물 정보: 『약학회지』제28권 제6호 (1984년), 305~311쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1984.12.30

영문 초록

Relationship between hypertension and monoamine oxidase (MAO) activity in rat brain and the change of this relationship by presynaptic alpha-receptor agonist were studied. Animals were divided into three groups. Group I was composed of normotensive Sprague-Dawley rats (NR), group II of spontaneously hypertensive rats (SHR) and group III of acquired hypertensive rats induced by deoxycorticosterone acetate (DOCA) and NaCl treatment. Clonidine, a presynaptic alpha-receptor agonist, was administered to groups II and III. Blood pressures and MAO activities were measured in each group. MAO activities in the brain of SHR were lower than those of NR. Animals in group II received clonidine which lowered blood pressures but did not change MAO activities in the brain. DOCA and NaCl induced hypertension 21 days after these treatments in group III and did not cause any changes in brain MAO activity. Clonidine lowered blood pressures of group III but did not study suggest that abnormaly low MAO activities in SHR brain may be one of the underlying factors for the susceptibility to hypertension and that the decrease in noradrenergic neuronal activities through presynaptic alpha-receptor activation by clonidine may not be related to the changes of brain MAO activities.