Carbamide Peroxide 용액의 안정성

• 영문명: A Study on the Stability of Carbamide Peroxide Solution
• 발행기관: 대한약학회
• 저자명: 이계주(Gye Ju Rhee) 유병설(Byung Sul Yu)
• 간행물 정보: 『약학회지』제28권 제6호 (1984년), 299~303쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1984.12.30

영문 초록

In order to elucidate the effect of humidity and organic solvent on the decomposition of carbamide peroxide, the kinetic study was carried out. The carbamide peroxide was prepared from urea and 30%-hydrogen peroxide. The accelerated stability analysis for carbamide peroxide crystal in various relative humidity, and for 10%-carbamide peroxide solution of organic solvents were investigated. Both humidity and temperature were important factors influencing the decomposition rate of carbamide peroxide crystal. The higher the humidity and temperature, the greater was the reaction rate. The breakdown rate of crystal was observed as an apparent zero-order, and was faster than the rate of decomposition in dilute propylene glycol, glycerine or sorbitol solutions which were measured as an apparent first-order reaction. The more dilute to 10% the organic solvents of 1O%-carbamide peroxide, the slower was breakdown rate. It is, therefore, useful in the aspects of stability and economics to substitute solvent of carbamide peroxide topical solution (USP XXI) with 10%-propylene glycol or glycerine instead of anhydrous glycerine.