alpha-Piperidinoacetophenone의 Hydantoin 형성 반응

• 영문명: Bucherer Berg''s Reaction of alpha-Piperidinoacetophenone in the Formation of Hydantoin
• 발행기관: 대한약학회
• 저자명: 권순경(Soon Kyong Kwon) 서정진(Jung Jin Suh)
• 간행물 정보: 『약학회지』제27권 제3호 (1983년), 245~247쪽, 전체 3쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1983.09.30

영문 초록

In Bucherer-Berg''s reaction of alpha-piperidinoacetophenone with KCN and (NH4)2CO3 in dilute alcohol solution to form hydantoin, the expected 5-phenyl-5-piperidinomethylhydantoin was not formed. In this reaction alpha-piperidinomethyl group was eliminated and 5-phenylhydantoin was obtained. According to GC/MS study of the reaction mixture, the one of the chromatograms, which has mole peak 124, was identified as alpha-piperidinoacetonitrile. Under the pressurized condition, diphenylhydantil was obtained instead of 5-phenylhydantoin, which might have dimerized to the former