고체상태에서 Ampicillin Trihydrate의 안정성에 관한 연구

• 영문명: Stability Analysis of Ampicillin Trihydrate in Solid-State
• 발행기관: 대한약학회
• 저자명: 김종국(Chong Kook Kim) 곽효성(Hyo Sung Kwak) 신희종(Hee Jong Shin)
• 간행물 정보: 『약학회지』제25권 제1호 (1981년), 37~42쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1981.04.10

영문 초록

Penicillin derivatives have a stability problem by hydrolysis of their beta-lactam ring. At high temperature, crystal water is released from penicillin derivatives, especially ampicillin trihydrate and concerns itself in hydrolysis. Penicillin derivatives having crystal water show different crystal states and different stability according to the variation of different condition on the process of manufacturing. The stability of ampicillin trihydrate in solid states was determined. Physico-pharmaceutical properties of this compound were determined by using IR spectra, X-ray powder diffraction and differential thermal analysis (DTA).