Fentiazac의 항염증. 진통 및 소화기궤양 형성작용에 관한 연구

• 영문명: Anti-inflammatory, Analgesic and Ulcerogenic Activities of Fentiazac
• 발행기관: 대한약학회
• 저자명: 김충규(Choong Kyu Kim) 김원배(Won Bae Kim) 양중익(Joong Ik Yang) 민신홍(Shin Hong Min)
• 간행물 정보: 『약학회지』제25권 제1호 (1981년), 9~14쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1981.04.10

영문 초록

Anti-infammatory, analgesic and ulcerogenic activities of fentiazac were investigated in comparison with those of acetylsalicylic acid, fenbufen, naproxen and phenylbutazone. On the anti-inflammatory activity in carrageenin-induced rat paw edema and the analgesic activity on writhing syndrome induced with acetic acid in mice, fentiazac displayed more potent effect than acetylsalicylic acid, fenbufen and phenylbutazone. But the ulcerogenic action of fentiazac on gastrointestinal tract in fasting rats was less than that of reference drugs. From these investigation, fentiazac seemed to indicate a poor correlation between the extent of anti-inflammatory activity and ulcerogenic action.