Warfarin 및 Digoxin 정제의 처방 용량 실태 및 조제 양식의 고찰

• 영문명: Study on the Prescribed Doses and Dispensing Patterns of Warfarin and Digoxin Tablets
• 발행기관: 대한약학회
• 저자명: 김윤숙 이승미 천부순
• 간행물 정보: 『약학회지』제58권 제1호 (2014년), 40~46쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.02.28

영문 초록

Drugs with a narrow therapeutic index (NTI) require very precise dosing. Warfarin and digoxin are the exam- ples of NTI-drugs and dosing of them varies widely for different patients. However, in South Korea, only two strengths of warfarin and one of digoxin are commercially available. This is a big barrier for the precise dispensing and has potential safety risks to patients, particularly to elderly patients. To find a potential solution to the problem, an analysis of the pre-scribed doses and dispensing patterns of those drugs was performed. Data were collected by computer-facilitated pre-scription review in a university hospital. The period screened was from May 1st, 2012 to April 30th, 2013. All the prescriptions with either warfarin or digoxin tablets were selected for this study and dispensing patterns were analyzed according to the prescribed doses. A total of 17,017 warfarin prescriptions were analyzed; 8,148 for inpatient prescriptions, 8,869 for outpatient prescriptions, respectively. Of the 23 kinds of prescribed doses, 2 mg (19.9%) was most frequent, fol-lowed by 3 mg (13.2%) and 2.5 mg (11.7%). By analyzing the dispensing patterns, 60.3% (10,253) of the prescriptions required pill splitting and 72.0% of them were for the patients 65 years old and over. On the other hand, 4,350 digoxin pre-scriptions were included in this study. Of the 6 kinds of prescribed doses, 0.125 mg (71.2%) was most frequent, followed by 0.0625 mg (20.2%). Among the prescriptions for digoxin, 92.0% (3,998) should be split and 65.7% of them were for the patients aged 65 years and over. Despite limitations of strengths, various doses of warfarin and digoxin were prescribed. Furthermore, more than half of the prescriptions that required pill splitting were for elderly patients. The results from this study suggest that different strengths of warfarin and digoxin should be provided for accuracy of dispensing and safety for patients receiving them.

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warfarin digoxin prescribed doses tablet strengths dispensing patterns