수영 훈련이 뇌허혈 유발 흰쥐의 해마 치아이랑에서 뇌신경생성과 기능적 능력에 미치는 영향

• 영문명: The Effects of Swim Training on Neurogenesis in the Hippocampal Dentate Gyrus and Functional Ability After Focal Ischemic Stroke in Rats
• 발행기관: 한국전문물리치료학회
• 저자명: 김호성(Ho-sung Kim) 김덕호(Deuk-ho Kim) 이정필(Jeong-pil Lee) 김영주(Young-joo Kim) 신영오(Young-oh Shin) 김상훈(Sang-hoon Kim) 권기욱(Ki-wook Kwon) 오재근(Jae-keun Oh)
• 간행물 정보: 『한국전문물리치료학회지』한국전문물리치료학회지 제12권 제3호, 11~21쪽, 전체 11쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2005.09.30

영문 초록

The present study was aimed at investigating the effect of swimming training on brain function after focal cerebral ischemia in rats. Therefore, this study was examined on neurogenesis in dentate gyrus of hippocampus using 5-bromo-2’-deoxyuridine (BrdU) to label proliferating cells and assessed the neurological response following focal cerebral ischemia in rats using neurological motor behavioral test. In an observer-blinded fashion, twenty male Sprague-Dawley (280~310 g, 7 weeks old) rats were divided into four groups: MCAO plus swimming group (ME, n₁-5), MCAO plus control group (MC, n₂-5), SHAM plus swimming group (SE, n₃=5), SHAM plus control group (SC, n₄=5). The results of this study were as follows 1) The limb placing time before and after swimming in the ME group were significantly longer than the MC group (p＜.05), the SE group were significantly longer than the SC group (p＜.01). 2) The balance beam scores before and after swimming in the ME group was higher than the SE group, the MC group was higher than the SC group but was not significantly different (p＞.001). 3) The foot fault index before and after swimming training in ME group was significantly lower (i.e., improved) than the MC group (p＜.001) and the SE group (p＜.001), the SE group was significantly lower (i.e., improved) than the SC group (p＜.001). 4) The mean number of BrdU-positive cells in the dentate gyrus in the ME group was significantly higher than the MC group (p＜.001) and the SE group (p＜.01). The MC group and the SE group was significantly higher than the SC group (p＜.001). 5) There was significantly correlation between limb placing time and number of BrdU positive cells on swimming training, there was positive correlation (r=-.503, p＜.0001) and between foot fault index and BrdU-positive cells number, there was negative correlation (r=-.503, p＜.05). However, between balance beam scores and BrdU-positive cells number, there was no correlation. In conclusion, the present study demonstrates that the role of swimming training improves behavioral motor function probably by enhancing cell proliferation in that hippocampus. This study provides a model for investigating the stroke rehabilitation that underlies neurogenesis and functional ability.

목차

Abstract

Ⅰ. 서론

Ⅱ. 연구방법

Ⅲ. 결과

Ⅳ. 고찰

Ⅴ. 결론

인용문헌

키워드

BrdU immunohistochemistry Focal cerebral ischemia Neurogenesis Neurological motor behavioral test Swimming training