항우울제 치료 반응의 예측인자로서의 CREB-Phosphorylation

• 영문명: CREB-Phosphorylation as a Predictor of Therapeutic Response to Antidepressants
• 발행기관: 대한노인정신의학회
• 저자명: 이유진(Yu Jin Lee) 임신원(Shinn Won Lim) 김수연(Soo Yeon Kim) 정재원(Jae Won Jung) 김진우(Jin Woo Kim) 명우재(Woo Jae Myung) 송지혜(Ji Hye Song) 김도관(Doh Kwan Kim)
• 간행물 정보: 『노인정신의학』노인정신의학 제14권 제1호, 38~43쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2010.06.30

영문 초록

Objectives : CREB (c-AMP response element binding protein) is known as a key mediator of the therapeutic response to antidepressants. We investigated the change of CREB-phosphorylation (pCREB) at the early point of the fluoxetine treatment to find out it can be a predictor for antidepressant response. Methods : We evaluated the pCREB of T - lymphocyte nuclear extracts from 18 depressed patients at 0 and 1th week during fluoxetine treatment (20 mg/day). Responders were defined as the>or =50 % reduction of HAM-D score in 4 weeks. We compared the changes of pCREB at 0 and 1th week between responders and non-responders. Results : The responders showed a significant increase of pCREB at week 1 compared with week 0. The HAM-D difference between week 0 and 4 was positively correlated with the change of pCREB response. Conclusion : These results suggest that the early change of pCREB in peripheral lymphocyte can predict the later response of antidepressant. The correlation showed pCREB directly reflects a response status to the antidepressant fluoxetine and clinical improvement.

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키워드

우울증 예측인자 치료 반응 CREB-phosphorylation Depression Predictors Therapeutic response