주요우울증에서 아드레날린 알파 2 수용체 유전자 다형성과 Mirtazapine 치료반응의 연관성에 대한 연관연구

• 영문명: An Association Study between Various Adrenergic Alpha 2 Receptor Polymorphisms and Treatment Response to Mirtazapine in Major Depression
• 발행기관: 대한노인정신의학회
• 저자명: 김진우(Jin Woo Kim) 임신원(Shinn Won Lim) 최홍(Hong Choi) 김수연(Su Yeon Kim) 명우재(Woo Jae Myung) 이유진(Yu Jin Lee) 송지혜(Ji Hye Song) 정재원(Jae Won Chung) 김도관(Doh Kwan Kim)
• 간행물 정보: 『노인정신의학』노인정신의학 제14권 제1호, 20~26쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2010.06.30

영문 초록

Objectives : Genetic differences may contribute to the inter-individual differences in treatment response to antidepressants among patients suffering from major depression. This study investigated a possible association of treatment response to mirtazapine with various adrenergic alpha 2 receptor polymorphisms in major depressive patients. Methods : A 6-week naturalistic treatment study with a blinded outcome examined 84 Korean patients with major depression. Treatment response to mirtazapine was defined as ≥50% decrease in HAM-D scores at six weeks. In this study, four genetic polymorphisms were selected ; ADRA2A MspI, ADRA2A DraI, α2BDel301-303, andα2CDel322-325. Results : The Del/Del genotype of α2CDel322-325 exhibited a significant association with response to mirtazapine through multiple logistic regression. ADRA2A DraI, α2BDel301-303, and α2CDel322-325 did not showed a significant association with response to mirtazapine. Conclusion : Based on the finding that α2CDel322-325 polymorphism had an association with the mirtazapine response, we postulate that the polymorphism related to the mechanism of the antidepressant effect is important in predicting the response to antidepressants.

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단일염기다형성 약물유전학 주요우울증 아드레날린수용체 Mirtazapine Single nucleotide polymorphism Pharmacogenetics Major depression Adrenergic receptor