비소세포성폐암에서 방사선치료단독요법과 항암제 병합요법과의 치료결과 비교

• 영문명: Therapeutic Results of Radiation Therapy Alone and Combination with Chemotherapy in Non-Small Cell Lung Carcinoma
• 발행기관: 대한방사선종양학회
• 저자명: 김주리(Ju Ree Kim) 서현숙(Hyun Suk Suh)
• 간행물 정보: 『대한방사선종양학회지』제11권 제2호, 303~309쪽, 전체 7쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 1993.12.29

영문 초록

Between November 1983 and December 1992, 121 patients with non-small cell lung cancer were treated with radiotherapy alone or combined with chemotherapy in Inje University, Seoul Paik Hospital. Of these, 97 patients were evaluable and analyzed retrospectively. Group 1 (n=62)was treated with radiotherapy alone and group 2 (n=35) combined with chemotherapy. There were 7 patients, 1 patient with stage I and II ,20 patients, 11 patients with stage IIIA,28 patients, 20 patients with stage IIIB, and 6 patients, 3 patients with stage IV, respectively. Ninety percent of patients received more than 5000 cGy of radiation. Median survival of patients in group 1 was 9 months, group 2 was 15 months. Overall 2 year survival rates of group 1 and 2 were 37% and 27%, respectively. Relapse free survival rates at 2 year were 27% and 15%, respectively. Overall survival rates at 5 year for group 1 and 2 were 15% and 11%, and relapse free survival rates were 16% and 6%, respectively. Median survival of complete and partial responders was 47 months in group 1,18 months in group 2, and those of stable or progression was 6 months, 11 months, respectively. The proportion of locoregional relapse and distant metastasis was not significantly different between group 1 and 2. The majority of relapse developed within 2 years. Although 2 cases of severe esophagitis and myelosuppression were noted in group 2, the treatment related toxicity was relatively acceptable. Our analysis showed no statistically significant differences between the two treatment groups in terms of response rate, survival, and sites of relapse.

키워드

Non-small cell lung carcinoma Radiotherapy alone Combined modality with radiotherapy and chemotherapy