Omega 6 계열 불포화지방산의 세포독성과 항산화 효과

• 영문명: Cytotoxicity and Antioxidant Effects of Omega-6 Unsaturated Fatty Acid
• 발행기관: 한국인체미용예술학회
• 저자명: 백승화(Seung Hwa Baek) 한두석(Du Seok Han) 오현주(Hyun Ju Oh)
• 간행물 정보: 『한국인체미용예술학회지』한국인체예술학회지 제10권 제4호, 191~203쪽, 전체 13쪽
• 주제분류: 예술체육 > 예술일반
• 파일형태: PDF
• 발행일자: 2009.12.30

영문 초록

The cell growth inhibitory effect of n-6 unsaturated fatty acids on the growth of normal cell lines and cancer cell lines was evaluated by the 3-[4,5-dimethylthiazol-2-yl]-2,5-phenyltetrazolium bromide (MTT) and 2,3-bis-2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-caboxanilide (XTT) methods Linoleic acid (LA) and arachidonic acid (AA) on cancer cell lines decreased the cell viability and cell adhesion which was shown by the colorimetric method. The light microscopy of human skin melanoma cells showed that LA made severe morphological changes and decreased the number of cells in the concentration-dependent manner. The DPPH radical scavenging activity of AA was higher than that of LA. These results suggest that LA has a potential anticancer activity.

키워드

Unsaturated fatty acid(불포화지방산) cell viability(세포생존율) cell adhesion activity(세포부착저지능) DPPH radical scavenging activity(DPPH 라디칼 소거능)