비만 치료에 한약 추출물을 절식 보조제로 사용한 변형된 절식요법: 주제 범위 문헌 고찰

• 영문명: Modified Fasting Therapy Using Herbal Extract as Fasting Supplement for Obesity: A Scoping Review
• 발행기관: 한방비만학회
• 저자명: 이지호 박상현 한시현 김은진 금동호 박서현
• 간행물 정보: 『대한한방비만학회지』제24권 제2호, 201~226쪽, 전체 26쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2024.12.31

국문 초록

Objectives: Modified fasting therapy (MFT) using herbal extracts (HE) as a fasting supplement has been utilized for obesity treatment in Korean medicine (KM). This review aimed to evaluate the effectiveness and safety of MFT with HE on obesity, and provide a useful basis for predicting physiological changes during the treatment. Methods: Clinical studies of MFT with HE for obesity were searched from seven electronic databases up to April 30, 2024. Studies that combined other KM therapies for intervention were excluded. Outcome measures were as follows: body weight (BW), body mass index (BMI), waist circumference (WC), abdominal circumference (AC), lipid profile test, liver function test, renal function test, blood pressure, erythrocyte sedimentation, C-reactive protein (CRP), fast plasma glucose (FPG) and adverse events. Results: Thirteen trials with 582 patients met the inclusion criteria. Gamrosu and modified Yeonggyechulgam-tang were mainly used as fasting supplement. MFT were mainly conducted in 3 steps (relief period, fasting period, and refeeding period) while some were 4 steps including dietary period. BW, BMI, WC and AC tended to decrease. Also, triglyceride, guanosine triphosphate, blood urea nitrogen, blood urea nitrogen/creatine ratio, systolic blood pressure, diastolic blood pressure, CRP and FPG showed decreasing tendency, while total bilirubin tended to increase. No significant trends were detected for other indices. Only one trial reported adverse events. Conclusions: MFT with HE might be effective and safe for obesity, and could possibly manage obesity-related symptoms such as triglyceride levels, hypertension, diabetes, and inflammation. Further statistical validation and well-designed clinical trials are needed to substantiate its therapeutic and physiological effect.

목차

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대상 및 방법

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References

키워드

Modified fasting therapy Obesity Complementary therapies Physiological phenomena Biomarkers Review