Comparison of Anti-Adipogenesis and Protective Effects of Vegetable Sprouts against Intestinal Inflammation Induced by Lipopolysaccharides

• 발행기관: 한방비만학회
• 저자명: 김난경 백경완 이아영 김현영 김지현
• 간행물 정보: 『대한한방비만학회지』제24권 제2호, 121~132쪽, 전체 12쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2024.12.31

국문 초록

Objectives: We investigated the inhibitory effects of 12 species from vegetable sprouts ethanol extracts on adipogenesis and intestinal inflammation. Methods: The anti-adipogenesis effects of vegetable sprout extracts were evaluated using Oil Red O staining in differentiated 3T3-L1 cells. To confirm anti-inflammatory effects of vegetable sprout, we measured cell viability, lactate dehydrogenase (LDH) release, and inflammatory cytokines in lipopolysaccharide (LPS)-induced HT-29 human epithelial intestinal cells. Results: The triglyceride contents was inhibited by treatment of vegetable sprout extract in differentiated 3T3-L1 cells. Red radish (Pisum sativum) sprouts showed the highest inhibitory effect on lipid accumulation. Treatment of all vegetable sprouts increased cell viability and decreased LDH release, compared with LPS-treated HT-29 cells. Especially, red radish sprout-treated group exhibited the highest cell viability among other vegetable sprouts. In addition, 12 species of vegetable sprouts-treated HT-29 cells induced by LPS showed decreased interlukine-6 and tumor necrosis factor-α levels, compared to LPS-treated control group. Conclusions: This study suggests that the 12 species of vegetable sprouts, especially red radish sprouts, may be used as a potential agents that for anti-obesity and protection against intestinal inflammation.

목차

Introduction

Materials and Methods

Results

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References

키워드

Adipogenesis Vegetables Inflammation Lipopolysaccharide