Positive Association of TEAD1 With Schizophrenia in a Northeast Chinese Han Population

• 발행기관: 대한신경정신의학회
• 저자명: Yang Sun Lin Wen Yi-Yang Luo Wen-Juan Hu Hui-Wen Ren Ye Lv Cong Zhang Ping Gao Li-Na Xuan Guan-Yu Wang Cheng-Jie Li Zhi-Xin Xiang Zhi-Lin Luan
• 간행물 정보: 『Psychiatry Investigation』제20권 제12호, 1168~1176쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2023.12.31

국문 초록

Objective Schizophrenia is a complex and devastating psychiatric disorder with a strong genetic background. However, much uncer-tainty still exists about the role of genetic susceptibility in the pathophysiology of schizophrenia. TEA domain transcription factor 1 (TEAD1) is a transcription factor associated with neurodevelopment and has modulating effects on various nervous system diseases. In the current study, we performed a case–control association study in a Northeast Chinese Han population to explore the characteristics of pathogenic TEAD1 polymorphisms and potential association with schizophrenia. Methods We recruited a total of 721 schizophrenia patients and 1,195 healthy controls in this study. The 9 single nucleotide polymor-phisms (SNPs) in the gene region of TEAD1 were selected and genotyped. Results The genetic association analyses showed that five SNPs (rs12289262, rs6485989, rs4415740, rs7113256, and rs1866709) were sig-nificantly different between schizophrenia patients and healthy controls in allele or/and genotype frequencies. After Bonferroni correc-tion, the association of three SNPs (rs4415740, rs7113256, and rs1866709) with schizophrenia were still evident. Haplotype analysis re-vealed that two strong linkage disequilibrium blocks (rs6485989-rs4415740-rs7113256 and rs16911710-rs12364619-rs1866709) were globally associated with schizophrenia. Four haplotypes (C-C-C and T-T-T, rs6485989-rs4415740-rs7113256; G-T-A and G-T-G, rs16911710-rs12364619-rs1866709) were significantly different between schizophrenia patients and healthy controls. Conclusion The current findings indicated that the human TEAD1 gene has a genetic association with schizophrenia in the Chinese Han population and may act as a susceptibility gene for schizophrenia.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

키워드

Schizophrenia TEA domain transcription factor 1 Single nucleotide polymorphism Haplotype