Kinesin superfamily member 15 knockdown inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma

• 발행기관: 대한생리학회-대한약리학회
• 저자명: Yi Cai Qianyue Lai Xuan Zhang Yu Zhang Man Zhang Shaoju Gu Yuan Qin Jingshen Hou Li Zhao
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제27권 제5호, 457~470쪽, 전체 14쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2023.09.30

영문 초록

The aim of this study was to investigate the role of kinesin superfamily member 15 (KIF15) in nasopharyngeal carcinogenesis (NPC) and explore its underly-ing mechanisms. We employed various assays, including the CCK-8 assay, flow cy-tometry, the Transwell and scratch assay, Western blotting, and nude mice transplan-tation tumor, to investigate the impact of KIF15 on NPC. Our findings demonstrate that KIF15 plays a critical role in the proliferation, apoptosis, migration, and invasion of NPC cells. Furthermore, we discovered that silencing KIF15 inhibits cell prolifera-tion, migration, and invasion while promoting apoptosis, and that KIF15's effect on NPC cell growth is mediated through the PI3K/AKT and P53 signaling pathways. Additionally, we showed that KIF15 promotes nasopharyngeal cancer cell growth in vivo. Our study sheds light on the significance of KIF15 in NPC by revealing that KIF15 knockdown inhibits NPC cell growth through the regulation of AKT-related signaling pathways. These findings suggest that KIF15 represents a promising therapeutic tar-get for the prevention and treatment of NPC.

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키워드

Cell proliferation Kinesins Nasopharyngeal carcinoma