항우울제로 새롭게 등장한 ‘남용 물질’: 약리학적 기전, 항우울 효과, 오남용 가능성에 대한 고찰

• 영문명: “Drugs of Abuse” as a “New Antidepressant”: A Review on Pharmacological Mechanisms, Antidepressant Effects, and Abuse Potential
• 발행기관: 대한신경정신의학회
• 저자명: 안유석 박선영 강웅구
• 간행물 정보: 『신경정신의학』제61권 제4호, 243~253쪽, 전체 11쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2022.11.30

영문 초록

Drugs once classified as ‘substances of abuse’ are now drawing attention in the field of psychiatry as ‘new antidepressants’ for the management of treatment-resistant depression (TRD). Intranasal esketamine was approved by the Food and Drug Administration (FDA) for TRD and stimulants are being used as adjuvant therapy. Clinical studies on the use of cannabinoids, opiates, and psilocybin for depression are currently being conducted. However, even as they are being evaluated for their effectiveness, concern for their abuse potential is growing. In this article, the characteristics of ‘drugs of abuse’ that are approved or being developed as ‘new antidepressants’ are reviewed. Their historical background as mood-enhancers, pharmacological mechanisms, antidepressant effects, and risk of abuse are also discussed.

목차

서론

본론

결론

REFERENCES

키워드

Substance abuse Depression Antidepressant Self-medication Abuse potential