자살과 알코올 사용장애를 동반한 기분장애와의 연관성

• 영문명: Association Between Suicide Risk and Comorbidity of Mood Disorder and Alcohol Use Disorder: Using Common Data Model in Psychiatry
• 발행기관: 대한신경정신의학회
• 저자명: 조용혁(Yong Hyuk Cho) 이은영(Eunyoung Lee) 허은실(Eun Sil Her) 황규범(Gyubeom Hwang) 임기영(Ki-Young Lim) 노재성(Jai S
• 간행물 정보: 『신경정신의학』제60권 제3호, 232~239쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2021.08.31

영문 초록

Objectives This study determines the effects of comorbidity of mood disorder and alcohol use disorder on suicide behavior. Methods We converted data from the electronic medical records of one university hospital into a common data model and utilized it in our analysis. We selected 9551 patients with diagnosis codes of mood disorders or alcohol use disorders and divided them into three groups: mood disorder (MD) only, alcohol use disorder (AUD) only, and comorbidity of mood disorder and alcohol use disorder (MD+AUD). The mood disorder group was also subgrouped with depressive (DD) or bipolar affective disorder (BD) groups, and the comorbidity group was classified in the same way. Then, we applied logistic regression analysis to assess the risk of suicide attempts between the diagnostic groups. Subgroup analysis according to age also was conducted. Results The MD+AUD group had 2.7 (odd ratio [OR]=2.70, 95% confidence intervals [CI]=1.91- 3.81, p<0.0001) and the DD+AUD group had 2.78 (OR=2.78, 95% CI=1.95-3.98, p<0.0001) times higher risk of suicide attempts than the MD only and DD only group, respectively. Furthermore, according to the age subgroup, the risk of suicide attempts was the highest (OR=5.17, 95% CI=2.35-11.40, p<0.0001) in the DD+AUD group for those aged 40-59. There were no significant results in BD. Conclusion The results showed that the comorbidity of mood disorder and alcohol use disorder could increase suicide risk. This study suggested that alcohol use behavior needs to be assessed as well as mood symptoms for suicide prevention.

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알코올 사용장애 기분장애 자살 공통데이터모델 Alcohol use disorder Mood disorder Suicide Common data model