학술논문
The Interaction of Inflammatory Markers and Alcohol-Use on Cognitive Function in Korean Male Firefighters
이용수 12
- 영문명
- 발행기관
- 대한신경정신의학회
- 저자명
- Ji-Ae Yun Kyoung Sook Jeong Yeon-Soon Ahn Yuri Han Kyeong-Sook Choi
- 간행물 정보
- 『Psychiatry Investigation』제18권 제3호, 205~213쪽, 전체 9쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2021.03.31
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국문 초록
영문 초록
Objective Cognitive functions have been shown to become impaired due to alcoholism. Recently, neuroinflammation gained attention for playing a role in the neurotoxic effect of alcohol. However, there is limited data on the relationship between alcohol and cognitive function, based on the mechanism of inflammation. This study examined whether the interaction between alcohol use and pro-inflammatory biomarkers is related to cognitive function in Korean male firefighters. Methods A total of 474 firefighters were assessed for alcohol-related problems using CAGE, cognitive functions, and pro-inflammatory biomarkers (CRP, IL-6, TNF-α). Sequential multiple regression analyses were conducted to determine if inflammatory markers moderate the relationship between alcohol use and cognitive function. Results Only a decreased attentional function was associated with the interaction of alcohol use and inflammatory markers, after controlling for age, sex, body mass index, lipid profiles, smoking, depression, fatigue, self-reported hypertension, diabetes, and musculoskeletal problems. Conclusion This study revealed that the interaction between alcohol use and inflammation is related to attentional function in Korean male firefighters. Additionally, this cross-sectional study suggests that diminishing attention, related to alcohol use, may be based on the mechanism of inflammation.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
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