당뇨병이 없는 노인에서 당화혈색소와 심혈관 질환 발생 위험 인자의 관련성

• 영문명: Relationship of Hemoglobin A1c with Cardiovascular Disease Risk Factor in Non-Diabetic Elderly Populations
• 발행기관: 조선대학교 의학연구원
• 저자명: 강지인(Ji In Kang) 정재식(Jae Sik Jung) 소중해(Jung Hae So) 최영민(Young Min Choi) 김진화(Jin Hwa Kim) 김상용(Sang Yon
• 간행물 정보: 『The Medical Journal of Chosun University』제37권 제4호, 250~255쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.12.31

영문 초록

Glycosylated hemoglobin (HbA1c) is a useful index of mean blood glucose concentration over the preceding 2 to 3 months. Elevated HbA1C is associated with a higher incidence of microvascular and macrovascular complications in patient with diabetes mellitus. The aim of this study is to estimate the association of HbA1c with cardiovascular risk factor, especially in non-diabetic elderly population. After individuals previously diagnosed with diabetes, hypertension or dyslipidemia and those treated with hypoglycemic agent, antihypertensive agent, and lipid lowering agent were excluded, 370 adult (177 males and 193 females) aged over 60 years were included as the subject. HbA1c revealed a significant correlation with fasting plasma glucose, triglyceride, LDL cholesterol, and HDL cholesterol. According to analysis by sex, HbA1c revealed a significant correlation with fasting plasma glucose and LDL cholesterol in male, but with fasting plasma glucose and triglyceride in female. Multiple regression analysis showed that HbA1c had a positive association with triglyceride, LDL cholesterol, and a negative association with HDL cholesterol. These results demonstrated that the HbA1c level is correlated with cardiovascular risk factor in non-diabetic elderly population, and thus we suggest that HbA1c may predict cardiovascular risk as a useful tool in non-diabetic elderly population.

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키워드

HbA1c Cardiovascular risk factor Non diabetic elderly population