폐쇄성 수면 무호흡 증의 병인 및 기전

• 영문명: Pathogenesis and Mechanism of Obstructive Sleep Apnea
• 발행기관: 대한수면의학회
• 저자명: 최지호(Ji Ho Choi) 이승훈(Seung-Hoon Lee) 신철(Chol Shin)
• 간행물 정보: 『수면정신생리』제12권 제2호, 105~110쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2005.12.31

영문 초록

The pathogenesis and mechanism of obstructive sleep apnea (OSA) has been under investigation for over 25 years, but its etiology and mechanism remains elusive. Skeletal (maxillary and/or mandibular hypoplasia or retrodisplacement, inferior displacement of hyoid) and soft tissue (increased volume of soft tissue, adenotonsillar hypertrophy, macroglossia, thickened lateral pharyngeal walls) factors, pharyngeal compliance (increased), pharyngeal muscle factors (impaired strength and endurance of pharyngeal dilators and fixators), sensory factors (impaired mechanoreceptor sensitivity, impaired pharyngeal dilator reflexes), respiratory control system factors (unstable respiratory control) and so on facilitate collapse upper airway. Therefore, OSA may be a heterogeneous disorder, rather than a single disease entity and various pathogenic factors contribute to the OSA varies person to person. As a result, patients may respond to different therapeutic approaches based on the predominant abnormality leading to the sleep-disordered breathing.

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키워드

수면 무호흡 병인 기전 치료 Obstructive sleep apnea syndrome Pathogenesis Mechanism Treatment