학술논문
Effect of gemigliptin on cardiac ischemia/reperfusion and spontaneous hypertensive rat models
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- 영문명
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- Dae-Hwan Nam Jinsook Park Sun-Hyun Park Ki-Suk Kim Eun Bok Baek
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제23권 제5호, 329~334쪽, 전체 6쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2019.09.30
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국문 초록
영문 초록
Diabetes is associated with an increased risk of cardiovascular complications. Dipeptidyl peptidase-4 (DPP-IV) inhibitors are used clinically to reduce high blood glucose levels as an antidiabetic agent. However, the effect of the DPP-IV inhibitor gemigliptin on ischemia/reperfusion (I/R)-induced myocardial injury and hypertension is unknown. In this study, we assessed the effects and mechanisms of gemigliptin in rat models of myocardial I/R injury and spontaneous hypertension. Gemigliptin (20 and 100 mg/kg/d) or vehicle was administered intragastrically to Sprague–Dawley rats for 4 weeks before induction of I/R injury. Gemigliptin exerted a preventive effect on I/R injury by improving hemodynamic function and reducing infarct size compared to the vehicle control group. Moreover, administration of gemigliptin (0.03% and 0.15%) powder in food for 4 weeks reversed hypertrophy and improved diastolic function in spontaneously hypertensive rats. We report here a novel effect of the gemigliptin on I/R injury and hypertension.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
키워드
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