난독증 아동의 뇌백질 연결성 변화 : 환자-대조군 연구

• 영문명: Alteration of White Matter Integrity in Dyslexic Children : Case-Control Study
• 발행기관: 대한신경정신의학회
• 저자명: 박성열(Sung-Yeol Park) 유재현(Jae Hyun Yoo) 양민화(Minhwa Yang) 김보배(Bobae Kim) 김붕년(Bung Nyun Kim)
• 간행물 정보: 『신경정신의학』제58권 제2호, 146~150쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2019.05.30

영문 초록

Objectives To compare the white matter microstructure of dyslexic children with normal children using diffusion tensor imaging. Methods Twenty one dyslexic children and 24 normal control children were recruited in the second and third grade of elementary school students. The fractional anisotropy (FA) values of 20 representative white matter tracts were estimated from the diffusion tensor imaging data of each subject using the Johns Hopkins University–white matter tractography atlas to determine the difference in white matter integrity between the dyslexic children and normal children. Results Compared to the normal control group, the FA values of the left inferior longitudinal fasciculus [F(1,39)=5.908, p<0.05] and temporal part of the right superior longitudinal fasciculus [F(1,39)=7.328, p=0.010] were significantly higher in the dyslexic group and there was no significant difference in the other tracts. Conclusion In dyslexic children, compensatory pathways develop in the left inferior longitudinal fasciculus and in the temporal part of the right superior longitudinal fasciculus.

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키워드

Dyslexia White matter tract Diffusion tensor imaging Diffusion tractography Left inferior longitudinal fasciculus Right superior longitudinal fasciculus