반복되는 천명을 가진 학령 전기 소아에서 고장성 식염수와 Salbutamol 병용 흡입치료의 효과

• 영문명: The Effect of Nebulized 5% Hypertonic Saline and Salbutamol in Children with Recurrent Wheezing Episode
• 발행기관: 조선대학교 의학연구원
• 저자명: 송명곤(Myung Gon Song) 이화랑(Hwoa Rang Lee) 김용욱(Yong Wook Kim) 김경심(Kyoung Sim Kim) 김은영(Eun Young Kim) 김 령
• 간행물 정보: 『The Medical Journal of Chosun University』제42권 제4호, 93~99쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.12.31

영문 초록

There are reports that inhaling hypertonic saline with bronchodilator is helpful in the treatment of bronchiolitis. However, further studies are needed to determine if it is helpful to inhale hypertonic saline with bronchodilator in children with recurrent wheezing. We aimed to investigate the effect of hypertonic saline inhalation in children with recurrent wheezing. A total of 40 patients under 6 years of age admitted to Kwangju Christian Hospital from December 2014 to May 2016 were enrolled. Patients were randomly assigned to receive salbutamol. In the control group (n=21), salbutamol (2.5-5 mg / 0.5-1 mL) was inhaled four times a day with physiological saline (0.9% normal saline 1-3 mL). In the experimental group (n=19), the same amount of hypertonic saline (5% saline 1-3 mL) was inhaled four times a day instead of physiological saline. We compared the duration of wheezing remission between patients who had recurrent wheezing (n=40). There was no difference in the duration of wheezing remission in patients who had recurrent wheezing. But the hypertonic saline inhalation group had a lower post treatment clinical score on the 2nd-3rd day of admission than the physiological saline inhalation group. In this study, hypertonic saline inhalation therapy was not significantly effective in the treatment of recurrent wheezing. More additional research is needed to determine whether inhaled hypertonic saline is effective in the treatment of recurrent wheezing.

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대상 및 방법

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키워드

Hypertonic saline Normal saline Children Wheezing Bronchiolitis