The Effects of Ulinastatin against the Development of Neuropathic Pain Is Involved with Changing the Levels of IL-6, not IL-10

• 영문명: The Effects of Ulinastatin against the Development of Neuropathic Pain Is Involved with Changing the Levels of IL-6, not IL-10
• 발행기관: 조선대학교 의학연구원
• 저자명: Jun Hee Park Seon Hee Oh Dong Jun Kim Hwa Song Jong Sang Hun Kim Kyung Joon Lim Myung Ha Yoon Ki Tae
• 간행물 정보: 『The Medical Journal of Chosun University』제40권 제4호, 145~148쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2015.12.31

영문 초록

Background: We evaluated the effect of ulinastatin on paw withdrawal threshold (PWT), IL-6, and IL-10 in SD rats after spinal nerve ligation (SNL). Methods: Group C received N/S and Group E received ulinastatin IV for three days following SNL. PWT, IL-6, and IL-10 were measured on the 3^rd, 5^th, and 7^th day. Results: Group E showed higher PWT compared to group C. IL-6 was lower in group E than in group C. No differences in IL-10 were observed between group C and group E. Conclusion: Ulinastatin increased the PWT and its effect appears to be involved with IL-6, not IL-10.

목차

Introduction

Materials and Methods

Results

Discussion

키워드

Interleukin-6 Interleukin-10 Neuropathic pain Rats Urinary trypsin inhibitor