일주기리듬의 조절이상이 양극성장애의 핵심 발병 기전일까?

• 영문명: Is the Circadian Rhythm Dysregulation a Core Pathogenetic Mechanism of Bipolar Disorder?
• 발행기관: 대한신경정신의학회
• 저자명: 이헌정(Heon-Jeong Lee)
• 간행물 정보: 『신경정신의학』제57권 제4호, 276~286쪽, 전체 11쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2018.11.30

영문 초록

Circadian rhythm is a periodic and continuous change in physiological, behavioral, and mental characteristics that occurs in most organisms on the Earth, because the Earth rotates in a 24-hour cycle. The circadian system regulates daily rhythms of physiology and behavior, such as the sleep/wake cycle, body temperature, hormonal secretion, and mood. The influence of circadian rhythm is very powerful, but limited research has addressed its effects. However, many recent studies have shown that circadian dysregulation may play an important role in the pathogenesis of bipolar disorder. This review study examined current and noteworthy studies, including the authors’ own works, and proposes a possible clinical application of bipolar disorder based on evidence that circadian rhythm dysregulation in bipolar disorder may be a key pathogenetic mechanism.

목차

서론

일주기리듬과 기전

위상반응곡선(Phase Response Curve)

양극성장애에서 일주기리듬의 변동

환경적 요인

일주기리듬의 어긋남(Circadian Misalignment)

양극성장애와 주요우울장애

장극성장애의 예후와 일주기리듬

일주기리듬의 치료적 적용

결론

키워드

Bipolar disorder Circadian rhythm Pathogenetic mechanism 양극성장애 일주기리듬 발병기전