BDNF Methylation and Suicidal Ideation in Patients with Acute Coronary Syndrome

• 영문명: BDNF Methylation and Suicidal Ideation in Patients with Acute Coronary Syndrome
• 발행기관: 대한신경정신의학회
• 저자명: Hee-Ju Kang Kyung-Yeol Bae Sung-Wan Kim Il-Seon Shin Young Joon Hong Young-keun Ahn Myung Ho Jeong J
• 간행물 정보: 『Psychiatry Investigation』제15권 제11호, 1094~1097쪽, 전체 4쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2018.11.30

영문 초록

Objective Patients with acute coronary syndrome (ACS) are at an increased risk of suicide. It is well known that epigenetic mechanisms may explain the pathophysiology of suicidal behavior including suicidal ideation (SI), but no study has explored these mechanisms in ACS populations. Methods In total, 969 patients were initially recruited within 2 weeks of the acute coronary event and, 711 patients were successfully followed up 1 year after ACS. SI was evaluated using the relevant items on the Montgomery-Åsberg Depression Rating Scale and covariates potentially affecting SI were estimated. Results Brain-derived neurotrophic factor (BDNF) hypermethylation was associated with SI in both the acute and chronic phases of ACS, although the association was not statistically significant in the acute phase after applying Bonferroni’s correction. Conclusion These results suggested that BDNF hypermethylation may have played a role in an epigenetic predisposition for SI in ACS patients, particularly during the chronic phase.

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INTRODUCTION

METHODS

RESULTS

DISCUSSION

키워드

Acute coronary syndrome Suicidal ideation Brain-derived neurotrophic factor methylation Longitudinal study