학술논문
Association between Thioridazine Use and Cancer Risk in Adult Patients with Schizophrenia-A Population-Based Study
이용수 5
- 영문명
- Association between Thioridazine Use and Cancer Risk in Adult Patients with Schizophrenia-A Population-Based Study
- 발행기관
- 대한신경정신의학회
- 저자명
- Cheng-Chen Chang Ming-Hong Hsieh Jong-Yi Wang Nan-Ying Chiu Yu-Hsun Wang Jeng-Yuan Chiou Hsiang-Hsiu
- 간행물 정보
- 『Psychiatry Investigation』제15권 제11호, 1064~1070쪽, 전체 7쪽
- 주제분류
- 의약학 > 정신과학
- 파일형태
- 발행일자
- 2018.11.30
4,000원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
Objective Several cell line studies have demonstrated thioridazine’s anticancer, multidrug resistance-reversing and apoptosis-inducing properties in various tumors. We conducted this nationwide population-based study to investigate the association between thioridazine use and cancer risk among adult patients with schizophrenia.
Methods Based on the Psychiatric Inpatient Medical Claim of the National Health Insurance Research Database of Taiwan, a total of 185,689 insured psychiatric patients during 2000 to 2005 were identified. After excluding patients with prior history of schizophrenia, only 42,273 newly diagnosed patients were included. Among them, 1,631 patients ever receiving thioridazine for more than 30 days within 6 months were selected and paired with 6,256 randomly selected non-thioridazine controls. These patients were traced till 2012/12/31 to see if they have any malignancy.
Results The incidence rates of hypertension and cerebrovascular disease were higher among cases than among matched controls. The incidence of hyperlipidemia, coronary artery disease and chronic pulmonary disease did not differ between the two groups. By using Cox proportional hazard model for cancer incidence, the crude hazard ratio was significantly higher in age, hypertension, hyperlipidemia, cerebrovascular disease, coronary artery disease and chronic pulmornary disease. However, after adjusting for other covariates, only age and hypertension remained significant. Thioridazine use in adult patients with schizophrenia had no significant association with cancer.
Conclusion Despite our finding that thioridazine use had no prevention in cancer in adult patients with schizophrenia. Based on the biological activity, thioridazine is a potential anticancer drug and further investigation in human with cancer is warranted.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
해당간행물 수록 논문
- BDNF Methylation and Suicidal Ideation in Patients with Acute Coronary Syndrome
- What Is It to Be Mentally Healthy from the North Korean Refugees’ Perspective?: Qualitative Research on the Changes in Mental Health Awareness among the North Korean Refugees
- Association between Thioridazine Use and Cancer Risk in Adult Patients with Schizophrenia-A Population-Based Study
- Effects of an Online Imagery-Based Treatment Program in Patients with Workplace-Related Posttraumatic Stress Disorder: A Pilot Study
- Use of a Machine Learning Algorithm to Predict Individuals with Suicide Ideation in the General Population
- Increased Frontal Gamma and Posterior Delta Powers as Potential Neurophysiological Correlates Differentiating Posttraumatic Stress Disorder from Anxiety Disorders
- Predicting Suicidal Ideation in College Students with Mental Health Screening Questionnaires
- The Relationship between Plasma Oxytocin Levels and Social Anxiety Symptoms
- The Impacts of Childhood Trauma on Psychosocial Features in a Chinese Sample of Young Adults
- Extracellular Vesicles in Psychiatry Research in the Context of RDoC Criteria
- Screening Tool for Anxiety Disorders: Development and Validation of the Korean Anxiety Screening Assessment
- The Mixed-Features Specifier of Major Depressive Disorder in DSM-5: Is It Practical?
참고문헌
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!