Morphine과 Pentazocine의 혈장 Corticosterone 증가작용에 미치는 Naloxone 및 Diazepam의 영향

• 영문명: Influences of Diazepam and Naloxine on the increase of Plasma Corticosterone Level induced by Morphine and Pentazocine
• 발행기관: 대한약리학회
• 저자명: 전보권(Boe Gwun Chun) 박정율(Jung Yul Park) 조근행(Geun Haeng Cho) 김수경(Soo Kyung Kim)
• 간행물 정보: 『대한약리학잡지』제19권 제1호, 115~122쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1983.06.30

영문 초록

The influences of diazepam and naloxone on the increase of plasma corticosterone level induced by morphine, pentazocine, ACTH, or picrotoxin were investigated in male mice. The results obtained were summarized as follows: 1) The increase induced by morphine or pentazocine of plasma corticosterone level was not affected by naloxone pretreatment but markedly suppressed by diazepam pretreatment. 2) The increase induced by ACTH of plasma corticosterone level was not affected by diazepam or naloxone pretreatment. 3) The picrotoxin markedly increased plasma corticosterone level, and the inceease was not affected by diazepam or naloxone pretreatment. This above results suggest that the increase induced by opioids of plasma corticosterone level seems to be rather related with other than opiate- or GABArerecptor.