흰쥐 신조직내 Cyclic Nucleotide 함량에 미치는 Hydrocortisone과 Furosemide의 영향

• 영문명: Effect of Hydrocortisone and Furosemide on the Renal Cyclic Nucleotides Content in Rat
• 발행기관: 대한약리학회
• 저자명: 조규철(Kyu Chul Cho) 김인순(In Soon Kim) 양재하(Jae Ha Yang) 박영서(Young Suh Park)
• 간행물 정보: 『대한약리학잡지』제19권 제1호, 93~100쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1983.06.30

영문 초록

Hydrocortisone 5 mg/kg which exerts minimal effect on the renal function and furosemide 1 mg/kg which induces moderate amount of diuresis were injected intraperitoneally to study their effects on the renal cyclic nucleotides content in rats. 1) The renal tissue levels of cAMP were significantly increased by administration of hydrocortisone, but there was no significant change in the furosemide group compared with that of saline treated control group. Moderate elevation in renal cAMP level was noted by the combined administration of hydrocortisone and furosemide, but this elevation was less than that of hvdrocortisone treated group. 2) The renal cGMP level did not show nay remarkable change after the administration of hydrocortisone, however, there were a significant increase by the administration of furosemide alone or combination of both drugs. The level of renal cGMP was higher and maintained longer in the combined treated group than furosemide treated group. The result of this experiment indicates that the potentiating effect of hydrocortisone on the diuretic action of furosemide nay be related to the renal levels of cGMP rather than that of cAMP.