가토 적혈구 세포막 Na+, K+-ATPase활성에 미치는 Carbachol의 영향

• 영문명: The Effect of Carbachol on Na⁺, K⁺-ATPase Activity in Rabbit Erythrocyte Membrane
• 발행기관: 대한약리학회
• 저자명: 김옥진(Ok Jin Kim) 김낙두(Nak Doo Kim) 박찬웅(Chan Woong Park) 홍사악(Sa Ack Hong)
• 간행물 정보: 『대한약리학잡지』제18권 제2호, 69~78쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1982.12.31

영문 초록

Na⁺, K⁺-ATPase is a component of plasma membrane in almost all animal cell, and maintains ionic distribution and membrane potential of normal cell. In the mechanism of adrenergic transmission, it is relatively well known that drug-receptor combination leads to stimulate adenylate cyclase and so on. In the cholinergic transmisison, the mechanism is not well known but is simply interpreted as the change of membrane permeability results from acetylcholine receptor interaction. To study the relationship between cholinergic transmission and membrane Na⁺, K⁺-ATPase, the effect of carbachol on Na⁺, K⁺-ATPase activity in rabbit erythrocyte membrane is studied. The results are summarized as follows. 1) Total ATPase, Mg²⁺-ATPase and Na⁺, K⁺-ATPase of rabbit erythrocyte membrane show maximum activities at 1mM of tris-ATP. 2) Total ATPase activity tends to increase when treated with carbachol (10-^-9M-10^-3M). 3) The Mg²⁺-ATPase activity also tends to increase when treated with carbachol (10-^-9M-10^-3M). 4) The Na⁺, K⁺-ATPase activity is inhibited when treated with carbachol (10-^-9M-10^-7M). It is suggested that the inhibition of Na⁺, K⁺-ATPase by cholinergic drugs may be considered as one part of mechanism of cholinergic transmission.