신열판실험방법(新熱板實驗方法)에 의(依)한 Naloxone과 Diazepam이 Morphine 진통효과(鎭痛效果)에 미치는 영향(影響)에 관(關)한 검색(檢索)

• 영문명: A New Hot-Plate Method using Threshold Temperature; its Application on the Study of the Interaction between Naloxone or Diazepam and Morphine
• 발행기관: 대한약리학회
• 저자명: 문영환(Young-Hwan Moon) 전보권(Boe-Gwun Chun)
• 간행물 정보: 『대한약리학잡지』제18권 제2호, 45~50쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1982.12.31

영문 초록

Yeum et al. formulated a new hot-plate method using the threshold temperature, and there are some controversies on the effects of naloxone and diazepam on the antinociceptive action. In this paper, the comparison of three methods registering analgesic activity and the application of the new hot-plate method formulated by Yeum et al. on the study of the influences of naloxone and diazepam on the analgesic effect of morphine were tried in male mice. The results obtained were summarized as follows; 1) The least-square regression lines of the morphine analgesia plotted against log-dose showed the correlation coefficient of above 0.90, but the competitive antagonism produced by naloxone (0.1 mg/kg) against the analgesia was more prominently demonstated by the new hot-plate method than the other methods: original hot-plate method and electrical stimulation method. 2) In the experiment using the new hot-plate method, the log dose-response curve of morphine (y=7.30 x+49.80, r=0.998) was shifted to the right by the pretreatment of naloxone (0.1 mg/kg), but was slightly shifted to the left by the pretreatment of diazepam (2.5 mg/kg). This study suggests that for the analgesia experiment, the new hot-plate method is superior to the original hot-plate method or the electrical stimulation method, and that the potentiative effect of diazepam on the morphine anagesia is not significant.