국소마취제(局所麻醉劑)가 Sulfanilamide의 직장내(直腸內) 흡수(吸收)에 미치는 영향

• 영문명: The Influence of the Local Anesthetics on the Absorption of Sulfanilamide through the Rectum
• 발행기관: 대한약리학회
• 저자명: 하춘자(Ha, Chun-Ja) 이진환(Lee, Jin-Hwan) 최준식(Choi, Jun-Shik)
• 간행물 정보: 『대한약리학잡지』제9권 제1호, 53~58쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1973.06.30

영문 초록

Author attempts to determine the absorption of the sulfanilamide by the various suppositorial bases contained the local anesthetics through the rectum of the rabbit. The types of bases examined are four of lipophillic, hydrophillic and emulsion types such as oil in water and water in oil, otherwise the local anesthetics are procaine and lidocaine each other 2 and 20 percent in a suppository. The results are as follows; 1. The absorption of sulfanilamide is higher when they are combined with the local anesthetics than when single drugs of them are used. 2. The promotion of absorption by the local anesthetics, both the procaine and lidocaine, are higher when they are used 20 percent than 2 percent as the concentration. 3. In excellency of the suppositorial base, the order of the blood level is polyethylene glycol, oil in water, water in oil as emulson type and cacao butter.