Pentazocine의 가토혈당(家兎血糖), 혈청(血淸) Transaminase 및 Alkaline Phosphatase 활성도(活性度)에 대(對)한 작용(作用)

• 영문명: The Action of Pentazocine on the Blood Sugar Level, Serum Transaminase and Alkaline Phosphatase Activities in Rabbits
• 발행기관: 대한약리학회
• 저자명: 박정인(Park, Jung-In) 이운구(Lee, Woon-Ku) 홍권희(Hong, Kwon-Hee) 김양순(Kim, Yang-Soon)
• 간행물 정보: 『대한약리학잡지』제9권 제1호, 47~52쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1973.06.30

영문 초록

A benzomorphan derivative, pentazocine has both opioid agonistic actions and weak narcotic antagonistic activity. In this paper, authors attempted to study the dose response of pentazocine on the blood sugar level, serum transaminase and alkaline phosphatase activity in rabbits. Eighteen rabbits were devided into 3 groups, and each group were injected with pentazocine 5mg, 15mg, and 30mg/kg respectively. And metabolic effects were investigated measuring the change of blood sugar contents, serum transaminase (S-GOT, S-GPT) activities and alkaline phosphatase activities in rabbits. The results were obtained as follows; 1. Pentazocine significantly increased the blood sugar content in rabbits. 2. Pentazocine significantly increased the serum GOT activity but in the serum GPT activity, it significantly increased in large dose. 3. Pentazocine significantly increased serum alkaline phosphatase activity.