옥수수 수염의 물 추출물이 혈압에 미치는 영향

• 영문명: Effect of Water Extract of Maydis Stigma on Blood Pressure
• 발행기관: 대한약리학회
• 저자명: 박철훈(Park, Chul-Hoon) 하병국(Ha, Byoung-Kuk) 백운상(Paek, Un-Sang) 한시준(Hahn, See-Joon)
• 간행물 정보: 『대한약리학잡지』제8권 제2호, 21~26쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1972.12.31

영문 초록

Zea mays Linne, which belongs to Graminae family, has been ordinarily used as edibles and fodder. Its stigma, Maydis Stigma, has been discarded without any special application with the exception of being used as diuretic in the sphere of Chinese medicine. Moreover, the pharmacological research toward Maydis Stigma as a medicinal herb has not been regretfully undertaken at all. The authors hereby paid attention to this point of view and made experiment to find out whether the water extract of Maydis Stigma might possess some pharmacological effect on the blood pressure of the rats or not. LD₅₀ to the mice was determined and the experiment was performed making the use of several agents related to the blood pressure such as atropine, Avil, dichloroisoproterenol and hexamethonium. The blood pressure of the rats and rabbits was recorded with the equipment of polygraph (Grass model 7 DAB) and its accessory, Statham pressure transducer. The results of the experiment are as follows. 1. LD₅₀ to the mice weighing 20g is determined 1,125 mg/kg. 2. The blood pressure manifests the gradual decrease by the rate of -15.50 ± 3.32, -22.14 ± 8.73 and -46.25 ± 5.17 mmHg in proportion to ZW 25, 50 and 150mg/kg administered to the rats. 3. The blood pressure also manifests the same gradual decrease in proportion to ZW administered to the rabbits. 4. It is of significant difference to manifest the increase of +5.14 ± 4.65 mmHg in the rats pretreated with atropine as compared with -22.14 ± 8.73 mmHg of control group when administered each ZW 50mg/kg. 5. The administration of ZW 50 mg/kg to the rats pretreated with Avil, dichloroisoproterenol and hexamethonium does not manifest the significant difference in comparison with the control group.