삼정환의 랫드를 이용한 90일 반복 경구투여 독성시험

• 영문명: Repeated Dose 90-Day Oral Toxicity Study of Modified Samjung-Hwan in Sprague-Dawley Rats
• 발행기관: 한방비만학회
• 저자명: 김민지(Min-Jee Kim) 이명종(Myeong-Jong Lee) 김호준(Hojun Kim)
• 간행물 정보: 『대한한방비만학회지』제18권 1호, 36~49쪽, 전체 14쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2018.06.30

영문 초록

Objectives: The study is aimed at evaluating the possible toxicity in 90-day repeated oral administration of modified Samjung-hwan (mSJH) in Sprague-Dawley (SD) rats. This study was conducted to detect the no-observed adverse effect level (NOAEL). Methods: Modified SJH extract was administered orally in male and female SD rats at dose of 0, 1,000, 2,000, 4,000 mg/kg. Each group consisted of 10 rats of each gender. The modified SJH extract was given once a day for 90 days. We monitored the changes of mortalities, clinical signs, body weight changes, food consumption, ophthalmologic findings, urine analysis, hematology, serum biochemistry, necropsy findings, organ weights, histological markers of all animals treated with modified SJH extract during the study period. Results: There were no toxicologically significant changes in mortalities, clinical signs, body weight gains, food consumption, ophthalmologic findings, urine analysis, hematology, serum biochemistry, necropsy findings, organ weights, histological markers in any of rats tested. Conclusions: The NOAEL of the modified SJH extract in male rats and no observed effect level (NOEL) in female rats are considered 4,000 mg/kg.

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No-observed-adverse-effect Level Safety Toxicity tests