학술논문
당귀수산, 생강, 커큐민의 대사성 질환과 관련된 일과성 수용체 전압 이온통로조절에 관한 연구
이용수 127
- 영문명
- Effects of Dangkwisoo-San, Ginger and Curcumin on Transient Receptor Potential Melastatin 7 Channels
- 발행기관
- 한방비만학회
- 저자명
- 김병주(Byung Joo Kim)
- 간행물 정보
- 『대한한방비만학회지』제18권 1호, 10~18쪽, 전체 9쪽
- 주제분류
- 의약학 > 한의학
- 파일형태
- 발행일자
- 2018.06.30
4,000원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.
국문 초록
영문 초록
Objectives: Metabolic syndrome is correlated with increased cardiovascular risk and characterized by several factors, including visceral obesity, hypertension, insulin resistance, and dyslipidemia. Several members of a large family of nonselective cation entry channels, e.g., transient receptor potential (TRP) melastatin 7 (TRPM7) channels have been associated with the development of cardiovascular diseases. The purpose of this study was to investigate the effects of Dangkwisoo-san, ginger and curcumin on TRPM7 channel.
Methods: Human embryonic kidney (HEK) 293 cells stably transfected with the TRPM7 expression vectors were maintained in Dulbecco s modified Eagle s medium (DMEM) supplemented with 10% fetal bovine serum (FBS), 1% penicillin/streptomycin, 5 μg/mL blasticidin, and 0.4 mg/mL zeocin in a humidified 20% O2/10% CO2 atmosphere at 37℃. Whole-cell patch clamp recordings were obtained using an Axopatch 700B amplifier and pClamp v.10.4 software, and signals were digitalized at 5 kHz using Digidata 1422A.
Results: Dangkwisoo-san extract (100, 200, 300, 400, and 500 μg/mL) inhibited the outward and inward TRPM7 whole-cell currents at dose dependent manner and the half maximal inhibitory concentration (IC)50 of Dangkwisoo-san was 218.3 μg/mL. Also, ginger extract (100, 200, 300, 400, and 500 μg/mL) inhibited the outward and inward of TRPM7
whole-cell currents in a dose dependent manner and the IC50 of ginger was 877.2 μg/mL. However, curcumin had no effects on TRPM7 whole-cell currents.
Conclusions: These results suggest that both Dangkwisoo-san and ginger have good roles to inhibit the TRPM7 channel, suggesting that Dangkwisoo-san and ginger are considered one of the candidate agents for the treatment of metabolic syndrome such as cardiovascular disease.
목차
서론
재료 및 방법
결과
고찰
결론
해당간행물 수록 논문
참고문헌
관련논문
의약학 > 한의학분야 BEST
더보기의약학 > 한의학분야 NEW
- 척추신경추나의학회지 제19권 제2호 목차
- 청소년 특발성 척추측만증에 대한 추나 치료의 임상적 효능 : 체계적 문헌 고찰 및 메타분석
- 자폐스펙트럼 장애 치료를 위한 수기요법 경혈에 관한 임상적용 현황분석
최근 이용한 논문
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!