가미 태음조위탕과 저열량 식이를 병행한 체중 감량 프로그램에서 발생한 이상 반응 분석

• 영문명: Analysis of Adverse Events in Weight Loss Program in Combination with ‘Gamitaeeumjowee-Tang’ and Low-Calorie Diet
• 발행기관: 한방비만학회
• 저자명: 윤나라(Na-Ra Yoon) 유영재(Young-Jae Yoo) 김민지(Min-ji Kim) 김서영(Seo-Young Kim) 임영우(Young-Woo Lim) 임형호(Hyung H
• 간행물 정보: 『대한한방비만학회지』제18권 1호, 1~9쪽, 전체 9쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2018.06.30

영문 초록

Objectives: The objective of this study was to assess the safety of Gamitaeeumjowee-tang by analyzing adverse events in weight loss program in combination with Gamitaeeumjoweetang and low-calorie diet. Methods: A retrospective review of adverse events in weight loss program in combination with Gamitaeeumjowee-tang and low-calorie diet from the electronic medical chart (n=124) between June 2015 and December 2016 was conducted. Three Korean Medicine Doctors (KMDs) reviewed adverse events for two times, during week 2 to 4 and at week 10, after starting weight loss program. Adverse events were evaluated in terms of causality, severity and system-organ classes. Also, agreement among the three KMDs was made through further discussion in case of disagreement after independent review. Results: The overall rate of adverse events was 37.1% during week 2 to 4 and 16.9% at week 10. For causality of adverse events using the World Health Organization-Uppsala Monitoring Centre causality categories, 52.2% were evaluated possible at week 2-4 and 57.1% were evaluated unlikely at week 10. All symptoms were evaluated as mild by LDS scale. Nausea (15, 12.1%) was the most frequent adverse event at week 2-4 and dizziness (6, 4.8%) was the most common at week 10. Conclusions: Adverse events decreased over time. There were no serious adverse events and none of the subjects were dropped due to adverse events. Continuous study is needed to prove the safety of Gamitaeeumjowee-tang for treating obesity.

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키워드

Gamitaeeumjowee-tang Adverse drug event Safety Weight loss program Low-calorie diet